Lung cancer is the leading cause of cancer-related deaths in the United States. Tobacco smoking is the leading cause of lung cancer. However, people who smoke tobacco aren’t the only ones at risk of developing lung cancer.
The Centers for Disease Control and Prevention (CDC) estimates that 10% to 20% of lung cancer cases each year happen in people who never smoke.
Nonsmokers can develop lung cancer if they are exposed to secondhand smoke, air pollution, radioactive gases such as radon, asbestos, diesel exhaust, or other harmful chemicals.
According to the CDC, about 50% to 60% of lung cancers found in nonsmokers are adenocarcinomas, which is a type of non-small cell lung cancer that begins in the cells that line the tiny air sacs in the lungs and make substances such as mucus. Additionally, about 10% to 20% are squamous cell carcinomas, cancer that forms in the thin, flat cells lining the inside of the lungs, and 6% to 8% are small cell lung cancers, and the rest are other types of lung cancer.
Lung cancers in nonsmokers are often different than those that are in smokers, as they usually develop in younger people, and often have certain gene changes that differ from those in tumors found in smokers.
A person’s genes can influence their risk of developing certain diseases, including some types of cancer, as some genes help control when cells grow, divide into new cells, and die. These genes are oncogenes and tumor suppressor genes.
Oncogenes help cells grow, divide, or stay alive. Tumor suppressor genes help control cell division or cause cells to die at the right time.
Cancer can develop when any DNA changes that activate oncogenes or deactivate tumor suppressor genes occur. These changes in many different genes are usually needed to cause cancer to develop. The two primary types of gene changes are inherited gene changes and acquired gene changes.
Inherited gene changes are gene changes passed down from a person’s parents. These inherited changes to a person’s DNA may increase their risk of developing certain cancers.
Acquired gene changes cannot be inherited but are acquired during a person’s lifetime and may occur in any individual cell. Certain acquired gene changes can affect the cell’s ability to control how it grows and will ultimately mutate a non-cancer cell into a cancer cell.
It is more common for nonsmoking women, especially Asian nonsmoking women, to develop lung cancer, as they are more than twice as likely to develop it as male nonsmokers. This is due to women having an acquired gene change, such as epidermal growth factor receptor (EGFR).
Symptoms of lung cancer are the same for smokers and nonsmokers. Lung cancer symptoms include:
- Feeling tired or weak all the time
- Loss of appetite
- A cough that doesn’t go away or gets worse
- Coughing up blood or rust-colored phlegm
- Chest pains
- Shortness of breath
- Unexplained weight loss
- Hoarseness
- Bronchitis or pneumonia that doesn’t go away or keeps coming back
- Wheezing
If a smoker is exhibiting symptoms of lung cancer, they should see a healthcare provider.
Although there isn’t any screening guidance for nonsmokers, taking steps such as being aware of lung cancer symptoms and reducing exposure to air pollutants and radon can help reduce your risk of developing lung cancer. Some additional steps include:
- Avoid secondhand smoke
- Monitor the air quality in your community
- Test your home for radon
- Protect yourself at work by avoiding any chemicals or cleaning products that contain carcinogens
If you would like to learn more about cancer treatments for lung cancer, or to learn more about our cancer care program, you can schedule an appointment with an oncologist at our MediSys Health Network Cancer Center by calling (718) 206-6742.
All content of this newsletter is intended for general information purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Please consult a medical professional before adopting any of the suggestions on this page. You must never disregard professional medical advice or delay seeking medical treatment based upon any content of this newsletter. PROMPTLY CONSULT YOUR PHYSICIAN OR CALL 911 IF YOU BELIEVE YOU HAVE A MEDICAL EMERGENCY.

Follow




