What May Cause Lung Cancer in Nonsmokers?

Posted on January 22, 2026 by Patrick Hercules

Lung cancer is the leading cause of cancer-related deaths in the United States. Tobacco smoking is the leading cause of lung cancer. However, people who smoke tobacco aren’t the only ones at risk of developing lung cancer.

The Centers for Disease Control and Prevention (CDC) estimates that 10% to 20% of lung cancer cases each year happen in people who never smoke.

Nonsmokers can develop lung cancer if they are exposed to secondhand smoke, air pollution, radioactive gases such as radon, asbestos, diesel exhaust, or other harmful chemicals.

According to the CDC, about 50% to 60% of lung cancers found in nonsmokers are adenocarcinomas, which is a type of non-small cell lung cancer that begins in the cells that line the tiny air sacs in the lungs and make substances such as mucus. Additionally, about 10% to 20% are squamous cell carcinomas, cancer that forms in the thin, flat cells lining the inside of the lungs, and 6% to 8% are small cell lung cancers, and the rest are other types of lung cancer.

Lung cancers in nonsmokers are often different than those that are in smokers, as they usually develop in younger people, and often have certain gene changes that differ from those in tumors found in smokers.

A person’s genes can influence their risk of developing certain diseases, including some types of cancer, as some genes help control when cells grow, divide into new cells, and die. These genes are oncogenes and tumor suppressor genes.

Oncogenes help cells grow, divide, or stay alive. Tumor suppressor genes help control cell division or cause cells to die at the right time.

Cancer can develop when any DNA changes that activate oncogenes or deactivate tumor suppressor genes occur. These changes in many different genes are usually needed to cause cancer to develop. The two primary types of gene changes are inherited gene changes and acquired gene changes.

Inherited gene changes are gene changes passed down from a person’s parents. These inherited changes to a person’s DNA may increase their risk of developing certain cancers.

Acquired gene changes cannot be inherited but are acquired during a person’s lifetime and may occur in any individual cell. Certain acquired gene changes can affect the cell’s ability to control how it grows and will ultimately mutate a non-cancer cell into a cancer cell.

It is more common for nonsmoking women, especially Asian nonsmoking women, to develop lung cancer, as they are more than twice as likely to develop it as male nonsmokers. This is due to women having an acquired gene change, such as epidermal growth factor receptor (EGFR).

Symptoms of lung cancer are the same for smokers and nonsmokers. Lung cancer symptoms include:

Feeling tired or weak all the time

Loss of appetite

A cough that doesn’t go away or gets worse

Coughing up blood or rust-colored phlegm

Chest pains

Shortness of breath

Unexplained weight loss

Hoarseness

Bronchitis or pneumonia that doesn’t go away or keeps coming back

Wheezing

If a smoker is exhibiting symptoms of lung cancer, they should see a healthcare provider.

Although there isn’t any screening guidance for nonsmokers, taking steps such as being aware of lung cancer symptoms and reducing exposure to air pollutants and radon can help reduce your risk of developing lung cancer. Some additional steps include:

Avoid secondhand smoke

Monitor the air quality in your community

Test your home for radon

Protect yourself at work by avoiding any chemicals or cleaning products that contain carcinogens

If you would like to learn more about cancer treatments for lung cancer, or to learn more about our cancer care program, you can schedule an appointment with an oncologist at our MediSys Health Network Cancer Center by calling (718) 206-6742.

All content of this newsletter is intended for general information purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Please consult a medical professional before adopting any of the suggestions on this page. You must never disregard professional medical advice or delay seeking medical treatment based upon any content of this newsletter. PROMPTLY CONSULT YOUR PHYSICIAN OR CALL 911 IF YOU BELIEVE YOU HAVE A MEDICAL EMERGENCY.

Lung Cancer Awareness Month

Posted on November 21, 2025 by Patrick Hercules

November is Lung Cancer Awareness Month, an annual observance dedicated to increasing awareness about lung cancer, its risk factors, early detection, and treatment options.

Lung cancer is the number one cause of cancer death, claiming more lives each year than breast, prostate, ovarian, and kidney cancers combined.

Lung cancer is a kind of cancer that starts with the growth of cells in the lungs. It doesn’t usually cause symptoms early on; however, the symptoms of lung cancer occur when the disease is advanced. Signs and symptoms of lung cancer that happen in and around the lungs include:

A new cough that doesn’t go away

Chest pain

Coughing up blood

Hoarseness

Shortness of breath

Wheezing

In addition to the signs and symptoms of lung cancer in the lungs, some symptoms occur when the cancer spreads to other parts of the body, including:

Bone pain

Headaches

Losing weight without trying

Loss of appetite

Swelling in the face or neck

Lung cancer occurs when cells in the lungs develop changes in their DNA. A cell’s DNA holds instructions that tell a cell what to do. In healthy cells, the DNA gives instructions to grow and multiply at a set rate. The instructions also tell the cells to die at a set time.

In cancer cells, DNA changes give different instructions. The changes tell the cancer cells to make many more cells quickly. Cancer cells can keep living when healthy cells die, causing too many cells.

Cancer cells might form a tumor. The tumor can grow to invade and destroy healthy body tissue. In time, cancer cells can break away and spread to other parts of the body, causing metastatic cancer.

Smoking causes most lung cancer. It can cause lung cancer in both smokers and non-smokers who have been exposed to secondhand smoke. However, people who have never smoked or been exposed to secondhand smoke can develop lung cancer.

Researchers believe smoking causes lung cancer by damaging the cells that line the lungs. Cigarette smoke contains cancer-causing substances known as carcinogens. When cigarette smoke is inhaled, carcinogens immediately cause changes in the lung tissue. The body may be able to repair the damage at first, but with each repeated exposure, healthy cells lining the lungs become more damaged. Over time, the damage causes cells to change, eventually developing into cancer.

Lung cancer is divided into two major types based on the appearance of cells under a microscope. The two general types of lung cancer include:

Small-cell lung cancer

Non-small cell lung cancer

A lung cancer diagnosis often starts with an imaging test to look at the lungs for signs of cancer before it develops. Other tests used to diagnose lung cancer include:

Sputum cytology

Biopsy

There are also additional tests that can be performed if a person is diagnosed with lung cancer to see if the cancer has spread. These tests allow a healthcare provider to know what stage the cancer is in. The stages of lung cancer range from 1 to 4. These staging tests often involve imaging tests such as an MRI, CT scan, bone scans, and a PET scan. If the cancer is in stage 1, the cancer is small and only in the lung. As cancer grows larger or spreads outside of the lungs, the numbers get higher. Stage 4 lung cancer means the cancer has spread to other parts of the body.

Treatment for lung cancer usually begins with surgery to remove the cancer. However, if the cancer is very large or has spread to other parts of the body, surgery may not be possible. As an alternative, treatment may start with medicine and radiation instead. A healthcare team will consider many factors when creating a treatment plan. These factors may include:

Overall health

The type and stage of cancer

The patient’s preferences

Another type of treatment for lung cancer is palliative care. Palliative care specialists will work with the patient, their family, and healthcare team to provide extra support while the patient goes through their cancer treatment.

Unfortunately, there isn’t a sure way to prevent lung cancer. However, you can reduce your risk by not smoking or quitting smoking, avoiding secondhand smoke, eating a diet of fruits and vegetables, and exercising most days of the week.

If you would like to learn more about lung cancer treatments, or to learn more about our cancer care program, you can schedule an appointment with an oncologist at our MediSys Health Network Cancer Center by calling (718) 206-6742.

World Lung Cancer Day

Posted on August 1, 2025 by Patrick Hercules

August 1st is observed as World Lung Cancer Day. It is a day dedicated to the global initiative of raising awareness about lung cancer, its impact, and the importance of prevention, early detection, and advanced treatments.

According to the World Health Organization, lung cancer is the leading cause of cancer-related deaths among both men and women, and it is so prevalent that more people die from it than from colon, breast, and liver cancers combined every year.

World Lung Cancer Day was established in 2012 by the Forum of International Respiratory Societies (FIRS) in collaboration with other health organizations. The day focuses on educating the public about risk factors such as smoking, air pollution, and occupational exposures, while advocating for research and improved access to care.

World Lung Cancer Day serves as a platform to support those affected by the disease and to emphasize the critical need for collective action in the fight against lung cancer.

Lung cancer screening helps to identify cancer at an early stage when treatment can be most effective. Early detection through a low-dose computed tomography (LDCT) scan can improve survival rates in individuals with the disease.

The MediSys Health Network is committed to improving the morbidity and mortality associated with lung cancer. For more information about our program, please contact the Lung Cancer Screening Program at 718-206-LUNG (5864).

Lung Cancer Awareness Month

Posted on November 17, 2019 by Andrew Rubin

November is recognized as Lung Cancer Awareness Month. The importance of this designation is to bring awareness to the fact that Lung Cancer is responsible for approximately 25 percent of all cancer deaths. Lung cancer takes more lives each year than colon, breast, and prostate cancers combined.

Lung cancer is a form of cancer that starts in the lungs. In the early stages there may not be any signs or symptoms. A history of smoking definitely contributes to a higher risk of being diagnosed with the disease, though non-smokers also can develop lung cancer.

Signs and Symptoms of Lung Cancer include:
• A cough that doesn’t get better
• Coughing up blood
• Shortness of breath
• Chest pain
• Wheezing
• Hoarseness
• Weight loss that isn’t intentional

It is now recommended that certain patients who are over 55 years of age and have smoked for many years consider screening for lung cancer by doing a a low dose CAT scan of the lungs. This may detect cancers at an early stage where they may be more curable. It is important to have a conversation with your physician prior to performing a screening CT scan so that the patient understands the pros and cons of screening. For example, many scans will show small nodules (small spots in the lungs) that are not cancerous but will require follow-up and patient’s need to understand this and be prepared for this possibility.

There are several types of lung cancer based on their appearance under the microscope. These include small cell cancer and non-small cell cancer, which is a group of cancers that includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma.

Testing that can help make the diagnosis of cancer includes chest x-rays, CT scans, PET scans, examination of the sputum, bronchoscopy ( a test in which a fiber optic scope is passed into the lungs), and lung biopsies (which can be done by a needle although sometimes a surgical procedure is required). Not all tests will be required for every patient.

Once the diagnosis is established it is important to determine what stage the cancer is. Factors that go into staging cancer include the size of the tumor itself location and whether it has spread to the lymph nodes in the chest or to other parts of the body such as the brain, liver, bone or adrenal glands.

To schedule an appointment with a pulmonologist at Jamaica Hospital, please call 718-206-6742.

Types and Stages Of Lung Cancer

Posted on April 3, 2018 by Xavia Malcolm

Non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) are the two major types of lung cancer. About 80 to 85% of diagnosed cases of the disease are attributed to NSCLC and the remaining 10 to 15% to SCLC.

Once diagnosed, a doctor will try to determine how much cancer has spread; this process is known as staging. Different stages of the disease describe how much cancer is in the body and can help doctors to decide on suitable treatment options.

The staging system most commonly used for NSCLC is the American Joint Committee on Cancer (AJCC) TNM system. There are four stages which include:

Stage 1- Cancer is found only in the lungs and has not spread to lymph nodes.

Stage 2 – Cancer is found in the lungs and surrounding lymph nodes.

Stage 3- Cancer is found in the lungs, lymph nodes, and in the middle of the chest.

Stage 4- Cancer is found in the lungs, fluid in the area around the lungs, as well as other parts of the body and other organs.

The stages of SCLC are based on the results of biopsies, physical exams, imaging tests or any additional form of testing used to determine how far this type of cancer has advanced. Doctors typically use a two-stage system to help them to decide which form of treatment is best. The stages of SCLC are:

Limited Stage- This is when cancer is found in only one side of the chest and in the lymph nodes above the collarbone – on the same side of the chest.

Extensive Stage- This describes when cancer has spread to lungs, the lymph nodes and other parts of the body.

Treatment for each type of lung cancer varies by stage. Typical approaches for NSCLC may include surgery, radiation, immunotherapy or chemotherapy. Radiation or chemotherapy are the most common types of treatment used for patients diagnosed with SCLC.

Smoking cigarettes or other tobacco products contribute greatly to the development of lung cancer. Quitting smoking can reduce your risk of developing this deadly disease.

If you are ready to quit smoking, Jamaica Hospital Medical Center provides a free smoking cessation program. To learn about our Freedom From Smoking program please call, 718-206-8494 or visit www.JamaicaHospital.org.

Facts About Lung Cancer

Posted on September 30, 2016 by Michael Hinck

Lung cancer is a form of cancer that starts in the lungs. It is the leading cause of cancer death in the United States in both men and women. More people die each year from lung cancer than from colon, prostate ovarian, and breast cancer combined.

In the early stages there may not be any signs or symptoms. A history of smoking definitely contributes to a higher risk of being diagnosed with the disease, though non-smokers also can develop lung cancer. Smoking causes cancer by irritating the lining of the lungs. This causes changes in the lung tissue. It is believed that the effects of smoking may be reversible in the very early phases but repeated exposure to the chemicals found in smoke will eventually be irreversible.

Signs and Symptoms of Lung Cancer include:
• A cough that doesn’t get better
• Coughing up blood
• Shortness of breath
• Chest pain
• Wheezing
• Hoarseness
• Headache
• Weight loss that isn’t intentional

If lung cancer is suspected, a few tests to make the diagnosis definitive will be ordered. A chest x-ray will be performed and if there are any lesions found on the lung a CT scan will to get a better view of the lungs. An exam of the sputum can sometimes reveal lung cancer cells and to complete the diagnosis a lung biopsy will be done to examine the cells to see if they are cancerous.

Depending on the stage of the cancer, treatment options vary and can include chemotherapy, radiation and / or surgery. A common surgical option is called a lobectomy, removal one of the lobes of the lung.

There is no way to prevent lung cancer, but the best way to reduce your risk is to not smoke. If you do smoke, quit immediately. Also avoid second hand smoke, radon, and harmful carcinogens.

Cancers besides Lung Cancer Linked to Smoking

Posted on April 19, 2016 by Xavia Malcolm

Studies have found that tobacco use is responsible for 30 percent of all cancer deaths in the United States.

It is common knowledge that lung cancer is one of the leading causes of death among smokers; however, smoking tobacco is also linked to the development of other life-threatening forms of the disease. Besides lung cancer, tobacco smoke also increases the risk for cancers of the pancreas, esophagus, throat, kidney, mouth and cervix to develop.

It is more likely for cancer to spread throughout the body of a smoker than a non–smoker because:

The toxins found in cigarettes weaken the immune system, making it difficult for the body to fight cancer cells and prevent them from growing.
These poisons can alter or damage the DNA of cells. When a cell’s DNA is damaged, it is not able to function properly and can begin to grow out of control.

A smoker can reduce their risk of developing cancer simply by quitting. Research indicates that within five years of quitting, a person can lower their risk of getting cancer of the bladder, esophagus, and throat by as much as 50 percent. After ten years of quitting the risk of dying from lung cancer can also be reduced by half.

The journey to quit smoking can be difficult, but you do not have to do it alone. Jamaica Hospital’s smoking cessation team wants to help you develop a plan leading to your “quit day”. Our hospital has partnered with the American Lung Association to bring you Freedom from Smoking, a comprehensive and successful group-based smoking cessation program, for more information call 718-206-8494.