When people are experiencing allergy symptoms such as coughs, sneezes, a runny nose, congestion, and itchy eyes, nose, or throat, they turn to allergy medications like diphenhydramine to help quell them. Diphenhydramine is an over-the-counter (OTC) antihistamine that, when used as directed, is usually safe for occasional allergy or sleep symptoms. However, when diphenhydramine is misused and more than the recommended dosage is taken, it can cause serious health risks.
According to the Centers for Disease Control and Prevention (CDC), an estimated one million people are seen in U.S. hospital emergency departments for adverse drug events each year, and more than one-fourth are hospitalized.
Unfortunately, teenagers have been reportedly taking dangerously high doses of diphenhydramine intentionally to provoke hallucinations. In 2020, the U.S. Food and Drug Administration (FDA) warned that taking higher doses of diphenhydramine could lead to life-threatening complications, including heart problems, such as irregular heart rhythms, seizures, coma, or even death, after news reports of teenagers being admitted to emergency rooms or dying after a TikTok challenge encouraged them to misuse the allergy medication.
In addition to life-threatening complications, misusing diphenhydramine can lead to cognitive decline, psychiatric harm, and neurological injury.
The FDA recommends always reading the drug facts label on all over-the-counter medicines to find out if they contain diphenhydramine, how much and how often you should take them, and important safety information to avoid taking more than the dose listed and prevent serious health risks.
Here are some safety tips to reduce the risk of the potentially harmful effects of misusing diphenhydramine:
- Lock medicine away safely to prevent accidental poisoning
- Choose medicines that only treat the symptoms you have
- Be mindful that many medicines contain multiple ingredients that may interact with alcohol dangerously
- Look out for the same active ingredients in medicines taken at the same time, as it may result in an overdose
- Do not take medicines longer than needed or in higher doses
- Do not take medicines with side effects that impact your ability to drive safely or use heavy machinery until you are in an appropriate and safe environment
- Read the dosing directions carefully, especially when it comes to infants and children
- Be cautious when taking more than one medicine at a time, as drug-to-drug interactions can cause serious health effects and can even be fatal
If you or a loved one is experiencing a bad reaction or serious side effects to an allergy medication, you can schedule an appointment with a doctor at Jamaica Hospital Medical Center’s Ambulatory Care Center. Please call (718) 206-7001. Please call 911 if there is an emergency.
All content of this newsletter is intended for general information purposes only and is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Please consult a medical professional before adopting any of the suggestions on this page. You must never disregard professional medical advice or delay seeking medical treatment based upon any content of this newsletter. PROMPTLY CONSULT YOUR PHYSICIAN OR CALL 911 IF YOU BELIEVE YOU HAVE A MEDICAL EMERGENCY.

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